Uridine (Triacetyluridine 25 mg)

Uridine is one of the four nucleosides of RNA, and outside that role it does something unexpected: it is a rate-limiting precursor for phosphatidylcholine, the principal phospholipid of the neuronal membrane. Through the Kennedy pathway, uridine is converted to CTP and then to CDP-choline, which is combined with diacylglycerol to build membrane. Supply of uridine constrains that assembly line.

This matters for synapses in particular. Dendritic spines are membrane-hungry structures, and their formation and maintenance draw on the same phospholipid pool.

The obstacle is delivery. Plain uridine is degraded rapidly in the gut and by first-pass metabolism, and oral doses raise plasma levels only briefly. Triacetyluridine solves this by acetylating the molecule at three positions, which makes it considerably more lipophilic and far more resistant to breakdown; the acetyl groups are then cleaved by esterases in the body, liberating uridine. Gram-for-gram it delivers what plain uridine cannot, which is why 25 mg here is not the same proposition as 25 mg of the unmodified compound.

Supports normal phospholipid synthesis and the maintenance of healthy neuronal membranes.

60 capsules, 25 mg each. Hypoallergenic, no diluents, binders, or fillers.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.